Waist-hip ratio related genetic loci are associated with risk of impaired fasting glucose in Chinese children: a case control study.

ABSTRACT:

Background

The meta-analyses of genome-wide association studies identified several waist-hip ratio (WHR) related loci in individuals of European ancestry. Since the pattern of fat distribution and the relationship between fat distribution and glucose metabolism disturbance in Chinese are different from those in Europeans, the present study aimed to explore the individual and cumulative effects of WHR-related loci on glycemic phenotypes in Chinese children.

Methods

A total of 2030 children were recruited from two independent studies. Eleven single nucleotide polymorphisms (SNPs) were selected and genotyped using matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS). Logistic regression and linear regression model were used to examine the

SUBMITTER: Song QY 

PROVIDER: S-EPMC5934898 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature