Translating molecular detections into a simple temperature test using a target-responsive smart thermometer.

ABSTRACT: While it has been well recognized that affordable and pocket-size devices play a major role in environmental monitoring, food safety and medical diagnostics, it often takes a tremendous amount of resources to develop such devices. Devices that have been developed are often dedicated devices that can detect only one or a few targets. To overcome these limitations, we herein report a novel target-responsive smart thermometer for translating molecular detection into a temperature test. The sensor system consists of a functional DNA-phospholipase A₂ (PLA₂) enzyme conjugate, a liposome-encapsulated NIR dye, and a thermometer interfaced with a NIR-laser device. The sensing principle is based on the target-induced release of PLA₂ from the DNA-enzyme conjugate, whi

SUBMITTER: Zhang J 

PROVIDER: S-EPMC5935027 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature