A halogen bond-mediated highly active artificial chloride channel with high anticancer activity.

ABSTRACT: Chloride-selective transmembrane carriers or channels might have possible uses in treating channelopathies or cancers. While chloride carriers have been extensively investigated, the corresponding chloride channels have remained limitedly studied. Moreover, all hitherto reported channel systems lack clearly definable and readily modifiable positions in their structures for the reliable construction and combinatorial optimization of their ion transport properties. As a result, the existing channels are limited by their large molecular weight, weak activity or low anion selectivity. In this report, we describe a readily accessible and robust monopeptide-based scaffold for the reliable construction of halogen bond-mediated artificial anion channels via directional assembly of electron-

SUBMITTER: Ren C 

PROVIDER: S-EPMC5935034 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature