Understanding and measuring symptoms and health status in asthma COPD overlap: content validity of the EXACT and SGRQ.

ABSTRACT:

Background

Asthma-chronic obstructive pulmonary disease overlap (ACO) differs from asthma and chronic obstructive pulmonary disease (COPD) in demographics, phenotypic characteristics and outcomes, yet the patient experience of ACO is poorly characterized. We aimed to understand and compare the patient experience of symptoms and domains of impact in ACO relative to COPD, and assess the content validity of existing patient-reported outcome (PRO) instruments in ACO.

Methods

This US qualitative, interview study included patients who met American Thoracic Society/European Respiratory Society spirometric criteria for COPD. Additionally, patients with ACO demonstrated reversibility (forced expiratory volume in 1 s [FEV₁] increase ≥ 12% and ≥ 200 mL) to albuterol/salbutam

SUBMITTER: Nelsen L 

PROVIDER: S-EPMC5935047 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature