Direct and indirect hyperpolarisation of amines using parahydrogen.

ABSTRACT: Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) are two widely used techniques for the study of molecules and materials. Hyperpolarisation methods, such as Signal Amplification By Reversible Exchange (SABRE), turn typically weak magnetic resonance responses into strong signals. In this article we detail how it is possible to hyperpolarise the ¹H, ¹³C and ¹⁵N nuclei of a range of amines. This involved showing how primary amines form stable but labile complexes of the type [Ir(H)₂(IMes)(amine)₃]Cl that allow parahydrogen to relay its latent polarisation into the amine. By optimising the temperature and parahydrogen pressure a 1000-fold per proton NH signal gain for deuterated benzylamine is achieved at

SUBMITTER: Iali W 

PROVIDER: S-EPMC5935062 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature