CNS inflammation and macrophage/microglial biology associated with HIV-1 infection.

ABSTRACT: Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS) can result in neurological dysfunction with devastating consequences in a significant proportion of individuals with acquired immune deficiency syndrome. HIV-1 does not infect neurons directly but induces damage indirectly through the accumulation of activated macrophage/microglia (M/M) cells, some of which are infected, that release neurotoxic mediators including both cellular activation products and viral proteins. One mechanism for the accumulation of activated M/M involves the development in infected individuals of an activated peripheral blood monocyte population that traffics through the blood-brain barrier, a process that also serves to carry virus into CNS and establish local infection. A seco

SUBMITTER: Yadav A 

PROVIDER: S-EPMC5935112 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature