Interleukin-10 Directly Inhibits CD8⁺ T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity.

ABSTRACT: Chronic viral infections remain a global health concern. The early events that facilitate viral persistence have been linked to the activity of the immunoregulatory cytokine IL-10. However, the mechanisms by which IL-10 facilitates the establishment of chronic infection are not fully understood. Herein, we demonstrated that the antigen sensitivity of CD8⁺ T cells was decreased during chronic infection and that this was directly mediated by IL-10. Mechanistically, we showed that IL-10 induced the expression of Mgat5, a glycosyltransferase that enhances N-glycan branching on surface glycoproteins. Increased N-glycan branching on CD8⁺ T cells promoted the formation of a galectin 3-mediated membrane lattice, which restricted the interaction of key glycoproteins, ultimatel

SUBMITTER: Smith LK 

PROVIDER: S-EPMC5935130 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature