A meta-analytic review of the association between two common SNPs in miRNAs and lung cancer susceptibility.

ABSTRACT:

Background

MicroRNAs (miRNAs) are involved in many biological processes, including tumor suppression. Multiple studies have shown an association between the miRNA-196a2 rs11614913 and miRNA-146a rs2910164 polymorphisms and cancer risk. However, the implications of the reported data are debatable and inconclusive.

Materials and methods

Relevant articles were retrieved from the PubMed, EMBASE, China National Knowledge Infrastructure, and WanFang databases from January 1, 2007, to April 30, 2017. Studies were assessed based on designated inclusion and exclusion criteria, and data were manually extracted from relevant studies by two investigators. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to explore the association between two single-nucleotide

SUBMITTER: Xiao S 

PROVIDER: S-EPMC5935188 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature