Inactivation of nuclear factor κB by MIP-based drug combinations augments cell death of breast cancer cells.

ABSTRACT:

Background

Drug combination therapy to treat cancer is a strategic approach to increase successful treatment rate. Optimizing combination regimens is vital to increase therapeutic efficacy with minimal side effects.

Materials and methods

In the present study, we evaluated the in vitro cytotoxicity of double and triple combinations consisting of 1'S-1'-acetoxychavicol acetate (ACA), Mycobacterium indicus pranii (MIP) and cisplatin (CDDP) against 14 various human cancer cell lines to address the need for more effective therapy. Our data show synergistic effects in MCF-7 cells treated with MIP:ACA, MIP:CDDP and MIP:ACA:CDDP combinations. The type of interaction between MIP, ACA and CDDP was evaluated based on combination index being <0.8 for synergistic effect. Identifyi

SUBMITTER: Subramaniam M 

PROVIDER: S-EPMC5935191 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature