A Population Study of Common Ocular Abnormalities in C57BL/6N rd8 Mice.

ABSTRACT:

Purpose

The purpose of this study was to quantify the frequency and severity of ocular abnormalities affecting wild-type C57BL/6N mice, the most common strain used worldwide for the creation of single-gene knockouts.

Methods

A total of 2773 animals (5546 eyes) were examined at one colony at UC Davis and in three more colonies at the Institut Clinique de la Souris in Strasbourg, France. Mice were examined at 15 to 16 weeks postnatal age by performing anterior segment biomicroscopy, posterior segment examination by indirect ophthalmoscopy, intraocular pressure measurement, and optical coherence tomography of anterior and posterior segment structures.

Results

Common ocular findings in the C57BL/6N strain included corneal deposits (3%), increased optical density of the an

SUBMITTER: Moore BA 

PROVIDER: S-EPMC5935295 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature