Fabrication of self-assembling nanofibers with optimal cell uptake and therapeutic delivery efficacy.

ABSTRACT: Effective strategies to fabricate finite organic nanoparticles and understanding their structure-dependent cell interaction is highly important for the development of long circulating nanocarriers in cancer therapy. In this contribution, we will capitalize on our recent development of finite supramolecular nanofibers based on the self-assembly of modularly designed cationic multidomain peptides (MDPs) and use them as a model system to investigate structure-dependent cell penetrating activity. MDPs self-assembled into nanofibers with high density of cationic charges at the fiber-solvent interface to interact with the cell membrane. However, despite the multivalent charge presentation, not all fibers led to high levels of membrane activity and cellular uptake. The flexibility of the cationic

SUBMITTER: Xu D 

PROVIDER: S-EPMC5935509 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature