Egr2-independent, Klf1-mediated induction of PD-L1 in CD4⁺ T cells.

ABSTRACT: Programmed death ligand 1 (PD-L1)-mediated induction of immune tolerance has been vigorously investigated in autoimmunity and anti-tumor immunity. However, details of the mechanism by which PD-L1 is induced in CD4⁺ T cells are unknown. Here, we revealed the potential function of Klf1 and Egr2-mediated induction of PD-L1 in CD4⁺ T cells. We focused on the molecules specifically expressed in CD4⁺CD25^-LAG3⁺ regulatory T cells (LAG3⁺ Tregs) highly express of PD-L1 and transcription factor Egr2. Although ectopic expression of Egr2 induced PD-L1, a deficiency of Egr2 did not affect its expression, indicating the involvement of another PD-L1 induction mechanism. Comprehensive gene expression analysis of LAG3⁺ Tregs and i

SUBMITTER: Teruya S 

PROVIDER: S-EPMC5935736 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature