Effects of simvastatin in chronic obstructive pulmonary disease: Results of a pilot, randomized, placebo-controlled clinical trial.

ABSTRACT:

Introduction

Statins may have pleiotropic effects in COPD, but mechanisms remain unclear.

Objectives

To assess the pleiotropic effect of statins in patients with stable COPD on (1): lung function (2); pulmonary and systemic inflammation (3); endothelial function (vascular stiffness) and circulating vascular growth factors; and (4), serum uric acid levels.

Method

Pilot, double-blind, randomized, placebo-controlled clinical trial in 24 patients with stable COPD, all statin-naïve, who were randomized (1:1) to receive simvastatin 40 mg/24 h during 12 weeks (n = 12; 69.0 ± 7.3 years; post-bd FEV₁ 53.4 ± 10.0% pred.) or placebo (n = 12; 66.4 ± 4.6 years; post-bd FEV₁ 48.2 ± 12.6% pred.). Nine patients per group (total n = 18

SUBMITTER: Balaguer C 

PROVIDER: S-EPMC5935853 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature