Metabolomic profiles in breast cancer:a pilot case-control study in the breast cancer family registry.

ABSTRACT:

Background

Metabolomics is emerging as an important tool for detecting differences between diseased and non-diseased individuals. However, prospective studies are limited.

Methods

We examined the detectability, reliability, and distribution of metabolites measured in pre-diagnostic plasma samples in a pilot study of women enrolled in the Northern California site of the Breast Cancer Family Registry. The study included 45 cases diagnosed with breast cancer at least one year after the blood draw, and 45 controls. Controls were matched on age (within 5 years), family status, BRCA status, and menopausal status. Duplicate samples were included for reliability assessment. We used a liquid chromatography/gas chromatography mass spectrometer platform to measure metabolites. We calcu

SUBMITTER: Dougan MM 

PROVIDER: S-EPMC5935968 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature