DNA- and RNA-binding ability of oligoDapT, a nucleobase-decorated peptide, for biomedical applications.

ABSTRACT:

Background

Nucleobase-bearing peptides and their interaction with DNA and RNA are an important topic in the development of therapeutic approaches. On one hand, they are highly effective for modulating the nucleic-acid-based biological processes. On the other hand, they permit to overcome some of the main factors limiting the therapeutic efficacy of natural oligonucleotides, such as their rapid degradation by nucleases.

Methods and results

This article describes the synthesis and characterization of a novel thymine-bearing nucleoamino acid based on the l-diaminopropionic acid (l-Dap) and its solid phase oligomerization to α-peptides (oligoDapT), characterized using mass spectrometry, spectroscopic techniques, and scanning electron microscopy (SEM) analysis. The interaction of

SUBMITTER: Musumeci D 

PROVIDER: S-EPMC5936014 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature