Implications for paediatric shock management in resource-limited settings: a perspective from the FEAST trial.

ABSTRACT:

Background

Although the African "Fluid Expansion as Supportive therapy" (FEAST) trial showed fluid resuscitation was harmful in children with severe febrile illness managed in resource-limited hospitals, the most recent evidence reviewed World Health Organization (WHO) guidelines continue to recommend fluid boluses in children with shock according to WHO criteria "WHO shock", arguing that the numbers included in the FEAST trial were too small to provide reasonable certainty.

Methods

We re-analysed the FEAST trial results for all international definitions for paediatric shock including hypotensive (or decompensated shock) and the WHO criteria. In addition, we examined the clinical relevance of the WHO criteria to published and unpublished observational studies reporting shock

SUBMITTER: Houston KA 

PROVIDER: S-EPMC5936024 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature