Simple and inexpensive micromachined aluminum microfluidic devices for acoustic focusing of particles and cells.

ABSTRACT: We introduce a new method to construct microfluidic devices especially useful for bulk acoustic wave (BAW)-based manipulation of cells and microparticles. To obtain efficient acoustic focusing, BAW devices require materials that have high acoustic impedance mismatch relative to the medium in which the cells/microparticles are suspended and materials with a high-quality factor. To date, silicon and glass have been the materials of choice for BAW-based acoustofluidic channel fabrication. Silicon- and glass-based fabrication is typically performed in clean room facilities, generates hazardous waste, and can take several hours to complete the microfabrication. To address some of the drawbacks in fabricating conventional BAW devices, we explored a new approach by micromachining microfluidic cha

SUBMITTER: Gautam GP 

PROVIDER: S-EPMC5936479 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature