Social relationships, inflammation markers, and breast cancer incidence in the Women's Health Initiative.

ABSTRACT:

Objectives

Previous research has reported associations between social relationships and carcinogenesis. Inflammation is a potential mediator of these associations. To clarify these links for one tumor site, we examined associations between social relationships, circulating inflammation markers, and breast cancer incidence.

Materials and methods

Among 132,262 participants from the prospective Women's Health Initiative, we used linear and logistic regression to evaluate associations between social relationship characteristics (social support, social strain, social network size) and inflammation markers of C-reactive protein (CRP) and white blood cell count (WBC). Cox regression was used to evaluate associations between inflammation markers and breast cancer incidence, as well

SUBMITTER: Busch EL 

PROVIDER: S-EPMC5936641 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature