Characterization of basal gene expression trends over a diurnal cycle in Xiphophorus maculatus skin, brain and liver.

ABSTRACT: Evolutionarily conserved diurnal circadian mechanisms maintain oscillating patterns of gene expression based on the day-night cycle. Xiphophorus fish have been used to evaluate transcriptional responses after exposure to various light sources and it was determined that each source incites distinct genetic responses in skin tissue. However, basal expression levels of genes that show oscillating expression patterns in day-night cycle, may affect the outcomes of such experiments, since basal gene expression levels at each point in the circadian path may influence the profile of identified light responsive genes. Lack of knowledge regarding diurnal fluctuations in basal gene expression patterns may confound the understanding of genetic responses to external stimuli (e.g., light) since the dyna

SUBMITTER: Lu Y 

PROVIDER: S-EPMC5936649 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature