Expression signatures of early-stage and advanced medaka melanomas.

ABSTRACT: Melanoma is one of the most aggressive tumors with a very low survival rate once metastasized. The incidence of newly detected cases increases every year suggesting the necessity of development and application of innovative treatment strategies. Human melanoma develops from melanocytes localized in the epidermis of the skin to malignant tumors because of deregulated effectors influencing several molecular pathways. Despite many advances in describing the molecular changes accompanying melanoma formation, many critical and clinically relevant molecular features of the transformed pigment cells and the underlying mechanisms are largely unknown. To contribute to a better understanding of the molecular processes of melanoma formation, we use a transgenic medaka melanoma model that is well suit

SUBMITTER: Klotz B 

PROVIDER: S-EPMC5936653 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature