Interleukin-25 (IL-25) has a protective role in atherosclerosis development in the aortic arch in mice.

ABSTRACT: Atherosclerosis is a chronic inflammatory disease characterized by the entrapment of apolipoprotein B-containing lipoproteins in the arterial intima, leading to local inflammation. T helper (Th) cell 1-mediated immune responses have been associated with atherosclerosis, and the cytokine interleukin-25 (IL-25 or IL-17E) has been reported to potentially regulate Th1 cell- and Th17 cell-related immune responses. In this study, we evaluated the effects of complete IL-25 deficiency or of a temporal IL-25 blockade on atherosclerosis development in apolipoprotein E-deficient (Apoe^-/-) mice. Mice deficient in both apolipoprotein E and IL-25 (Apoe^-/-/IL-25^-/-) had more Th1 cells in the spleen, along with elevated plasma levels of IL-17 and an in

SUBMITTER: Mantani PT 

PROVIDER: S-EPMC5936805 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature