PcxL and HpxL are flavin-dependent, oxime-forming <i>N</i>-oxidases in phosphonocystoximic acid biosynthesis in <i>Streptomyces</i>.

ABSTRACT: Several oxime-containing small molecules have useful properties, including antimicrobial, insecticidal, anticancer, and immunosuppressive activities. Phosphonocystoximate and its hydroxylated congener, hydroxyphosphonocystoximate, are recently discovered oxime-containing natural products produced by Streptomyces sp. NRRL S-481 and Streptomyces regensis NRRL WC-3744, respectively. The biosynthetic pathways for these two compounds are proposed to diverge at an early step in which 2-aminoethylphosphonate (2AEPn) is converted to (S)-1-hydroxy-2-aminoethylphosphonate ((S)-1H2AEPn) in S. regensis but not in Streptomyces sp. NRRL S-481). Subsequent installation of the oxime moiety into either 2AEPn or (S)-1H2AEPn is predicted to be catalyzed by Pcx

SUBMITTER: Goettge MN 

PROVIDER: S-EPMC5936822 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature