<i>Leishmania naiffi</i> and <i>Leishmania guyanensis</i> reference genomes highlight genome structure and gene evolution in the <i>Viannia</i> subgenus.

ABSTRACT: The unicellular protozoan parasite Leishmania causes the neglected tropical disease leishmaniasis, affecting 12 million people in 98 countries. In South America, where the Viannia subgenus predominates, so far only L. (Viannia) braziliensis and L. (V.) panamensis have been sequenced, assembled and annotated as reference genomes. Addressing this deficit in molecular information can inform species typing, epidemiological monitoring and clinical treatment. Here, L. (V.) naiffi and L. (V.) guyanensis genomic DNA was sequenced to assemble these two genomes as draft references from short sequence reads. The methods used were tested using short sequence reads for L. braziliensis M2904 against

SUBMITTER: Coughlan S 

PROVIDER: S-EPMC5936940 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature