The Yin and Yang of Tyrosine Kinase Inhibition During Experimental Polymicrobial Sepsis.

ABSTRACT: Neutrophils are the first cells of our immune system to arrive at the site of inflammation. They release cytokines, e.g., chemokines, to attract further immune cells, but also actively start to phagocytose and kill pathogens. In the case of sepsis, this tightly regulated host defense mechanism can become uncontrolled and hyperactive resulting in severe organ damage. Currently, no effective therapy is available to fight sepsis; therefore, novel treatment targets that could prevent excessive inflammatory responses are warranted. Src Family tyrosine Kinases (SFK), a group of tyrosine kinases, have been shown to play a major role in regulating immune cell recruitment and host defense. Leukocytes with SFK depletion display severe spreading and migration defects along with reduced cytokine produ

SUBMITTER: Goncalves-de-Albuquerque CF 

PROVIDER: S-EPMC5936983 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature