The importance of α-CT and Salt bridges in the Formation of Insulin and its Receptor Complex by Computational Simulation.

ABSTRACT: Insulin hormone is an important part of the endocrine system. It contains two polypeptide chains and plays a pivotal role in regulating carbohydrate metabolism. Insulin receptors (IR) located on cell surface interacts with insulin to control the intake of glucose. Although several studies have tried to clarify the interaction between insulin and its receptor, the mechanism of this interaction remains elusive because of the receptor's structural complexity and structural changes during the interaction. In this work, we tried to fractionate the interactions. Therefore, sequential docking method utilization of HADDOCK was used to achieve the mentioned goal, so the following processes were done: the first, two pdb files of IR i.e., 3LOH and 3W11 were concatenated using modeller. The second, fl

SUBMITTER: Dehghan-Shasaltaneh M 

PROVIDER: S-EPMC5937078 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature