Introducing Potential Key Proteins and Pathways in Human Laryngeal Cancer: A System Biology Approach.

ABSTRACT: The most common malignant neoplasm of the head and neck region is laryngeal cancer which presents a significant international health problem. The present study aims to screen potential proteins related to laryngeal cancer by network analysis to further understanding disease pathogenesis and biomarker discovery. Differentially expressed proteins were extracted from literatures of laryngeal cancer that compare proteome profiling of patient›s tissue with healthy controls. The PPI network analyzed for up and down regulated proteins with Cytoscape Version 3.4. After PPI construction, topological properties of the two networks have been analyzed. Besides, by using MCODE. the Gene Ontology (GO) analysis, the related modules and pathways were examined. Our study screened 275 differentially changed

SUBMITTER: Peyvandi H 

PROVIDER: S-EPMC5937111 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature