Decarboxylative Annulation of α-Amino Acids with β-Ketoaldehydes.

ABSTRACT: Indolizidine and quinolizidine derivatives are readily assembled from l-proline or (±)-pipecolic acid and β-ketoaldehydes via a decarboxylative annulation process. These reactions are promoted by acetic acid and involve azomethine ylides as reactive intermediates.

SUBMITTER: Paul A 

PROVIDER: S-EPMC5937137 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature