Inferring Fitness Effects from Time-Resolved Sequence Data with a Delay-Deterministic Model.

ABSTRACT: A common challenge arising from the observation of an evolutionary system over time is to infer the magnitude of selection acting upon a specific genetic variant, or variants, within the population. The inference of selection may be confounded by the effects of genetic drift in a system, leading to the development of inference procedures to account for these effects. However, recent work has suggested that deterministic models of evolution may be effective in capturing the effects of selection even under complex models of demography, suggesting the more general application of deterministic approaches to inference. Responding to this literature, we here note a case in which a deterministic model of evolution may give highly misleading inferences, resulting from the nondeterministic properti

SUBMITTER: Nene NR 

PROVIDER: S-EPMC5937181 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature