Reexamining Dis/Similarity-Based Tests for Rare-Variant Association with Case-Control Samples.

ABSTRACT: A properly designed distance-based measure can capture informative genetic differences among individuals with different phenotypes and can be used to detect variants responsible for the phenotypes. To detect associated variants, various tests have been designed to contrast genetic dissimilarity or similarity scores of certain subject groups in different ways, among which the most widely used strategy is to quantify the difference between the within-group genetic dissimilarity/similarity (i.e., case-case and control-control similarities) and the between-group dissimilarity/similarity (i.e., case-control similarities). While it has been noted that for common variants, the within-group and the between-group measures should all be included; in this work, we show that for rare var

SUBMITTER: Wang C 

PROVIDER: S-EPMC5937191 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature