Protein Partitioning into Ordered Membrane Domains: Insights from Simulations.

ABSTRACT: Cellular membranes are laterally organized into domains of distinct structures and compositions by the differential interaction affinities between various membrane lipids and proteins. A prominent example of such structures are lipid rafts, which are ordered, tightly packed domains that have been widely implicated in cellular processes. The functionality of raft domains is driven by their selective recruitment of specific membrane proteins to regulate their interactions and functions; however, there have been few general insights into the factors that determine the partitioning of membrane proteins between coexisting liquid domains. In this work, we used extensive coarse-grained and atomistic molecular dynamics simulations, potential of mean force calculations, and conceptual models to des

SUBMITTER: Lin X 

PROVIDER: S-EPMC5937199 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature