Methods for addressing "innocent bystanders" when evaluating safety of concomitant vaccines.

ABSTRACT:

Purpose

The need to develop methods for studying the safety of childhood immunization schedules has been recognized by the Institute of Medicine and Department of Health and Human Services. The recommended childhood immunization schedule includes multiple vaccines in a visit. A key concern is safety of concomitant (same day) versus separate day vaccination. This paper addresses a methodological challenge for observational studies using a self-controlled design to investigate the safety of concomitant vaccination.

Methods

We propose a process for distinguishing which of several concomitantly administered vaccines is responsible for increased risk of an adverse event while adjusting for confounding due to relationships between effect modifying risk factors and concomitant vacc

SUBMITTER: Wang SV 

PROVIDER: S-EPMC5937260 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature