The CXCL12 rs1801157 polymorphism and risk of colorectal cancer: a meta-analysis.

ABSTRACT:

Background

The CXCL12 rs1801157 polymorphism is putatively associated with the risk of malignancy. However, research results are inconsistent regarding particular cancers, especially colorectal cancer (CRC).

Methods

We conducted a meta-analysis via a comprehensive literature search of the databases PubMed and Embase. Odds ratios and their corresponding 95% confidence intervals were extracted to assess comprehensively the association between the CXCL12 rs1801157 polymorphism and the risk of CRC.

Results

According to the following models, the correlation between the presence of the CXCL12 rs1801157 polymorphism and the risk of CRC was not statistically significant: allelic (G cf. A), heterozygous (GG cf. GA), homozygous (GG cf. AA), dominant (GG cf.

SUBMITTER: Xu K 

PROVIDER: S-EPMC5937488 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature