Genetic Evidence That Carbohydrate-Stimulated Insulin Secretion Leads to Obesity.

ABSTRACT:

Background

A fundamental precept of the carbohydrate-insulin model of obesity is that insulin secretion drives weight gain. However, fasting hyperinsulinemia can also be driven by obesity-induced insulin resistance. We used genetic variation to isolate and estimate the potentially causal effect of insulin secretion on body weight.

Methods

Genetic instruments of variation of insulin secretion [assessed as insulin concentration 30 min after oral glucose (insulin-30)] were used to estimate the causal relationship between increased insulin secretion and body mass index (BMI), using bidirectional Mendelian randomization analysis of genome-wide association studies. Data sources included summary results from the largest published metaanalyses of predominantly European ancestry for

SUBMITTER: Astley CM 

PROVIDER: S-EPMC5937525 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature