Structural, biological and biophysical properties of glycated and glycoxidized phosphatidylethanolamines.

ABSTRACT: Glycation and glycoxidation of proteins and peptides have been intensively studied and are considered as reliable diagnostic biomarkers of hyperglycemia and early stages of type II diabetes. However, glucose can also react with primary amino groups present in other cellular components, such as aminophospholipids (aminoPLs). Although it is proposed that glycated aminoPLs can induce many cellular responses and contribute to the development and progression of diabetes, the routes of their formation and their biological roles are only partially revealed. The same is true for the influence of glucose-derived modifications on the biophysical properties of PLs. Here we studied structural, signaling, and biophysical properties of glycated and glycoxidized phosphatidylethanolamines (PEs). By combin

SUBMITTER: Annibal A 

PROVIDER: S-EPMC5937679 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature