Structure and regulation of the human INO80-nucleosome complex.

ABSTRACT: Access to DNA within nucleosomes is required for a variety of processes in cells including transcription, replication and repair. Consequently, cells encode multiple systems that remodel nucleosomes. These complexes can be simple, involving one or a few protein subunits, or more complicated multi-subunit machines ¹ . Biochemical studies^2-4 have placed the motor domains of several chromatin remodellers in the superhelical location 2 region of the nucleosome. Structural studies of yeast Chd1 and Snf2-a subunit in the complex with the capacity to remodel the structure of chromatin (RSC)-in complex with nucleosomes^5-7 have provided insights into the basic mechanism of nucleosome sliding performed by these complexes. However, how larger, multi-subunit remodellin

SUBMITTER: Ayala R 

PROVIDER: S-EPMC5937682 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature