Renal papillary tip extract stimulates BNP production and excretion from cardiomyocytes.

ABSTRACT:

Background

Brain natriuretic peptide (BNP) is an important biomarker for patients with cardiovascular diseases, including heart failure, hypertension and cardiac hypertrophy. It is also known that BNP levels are relatively higher in patients with chronic kidney disease and no heart disease; however, the mechanism remains unclear.

Methods and results

We developed a BNP reporter mouse and occasionally found that this promoter was activated specifically in the papillary tip of the kidneys, and its activation was not accompanied by BNP mRNA expression. No evidence was found to support the existence of BNP isoforms or other nucleotide expression apart from BNP and tdTomato. The pBNP-tdTomato-positive cells were interstitial cells and were not proliferative. Unexpectedly, both the

SUBMITTER: Goto I 

PROVIDER: S-EPMC5937764 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature