Patterning mechanisms diversify neuroepithelial domains in the Drosophila optic placode.

ABSTRACT: The central nervous system develops from monolayered neuroepithelial sheets. In a first step patterning mechanisms subdivide the seemingly uniform epithelia into domains allowing an increase of neuronal diversity in a tightly controlled spatial and temporal manner. In Drosophila, neuroepithelial patterning of the embryonic optic placode gives rise to the larval eye primordium, consisting of two photoreceptor (PR) precursor types (primary and secondary), as well as the optic lobe primordium, which during larval and pupal stages develops into the prominent optic ganglia. Here, we characterize a genetic network that regulates the balance between larval eye and optic lobe precursors, as well as between primary and secondary PR precursors. In a first step the proneural factor Atonal (Ato) speci

SUBMITTER: Mishra AK 

PROVIDER: S-EPMC5937791 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature