Modelling steroidogenesis: a framework model to support hypothesis generation and testing across endocrine studies.

ABSTRACT:

Objective

Steroid hormones are responsible for the control of a wide range of physiological processes such as development, growth, reproduction, metabolism, and aging. Because of the variety of enzymes, substrates and products that take part in steroidogenesis and the compartmentalisation of its constituent reactions, it is a complex process to visualise and document. One of the goals of systems biology is to quantitatively describe the behaviour of complex biological systems that involve the interaction of many components. This can be done by representing these interactions visually in a pathway model and then optionally constructing a mathematical model of the interactions.

Results

We have used the modified Edinburgh Pathway Notation to construct a framework diagram descri

SUBMITTER: O'Hara L 

PROVIDER: S-EPMC5937803 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature