Theta Oscillations in the Human Medial Temporal Lobe during Real-World Ambulatory Movement.

ABSTRACT: The theta rhythm-a slow (6-12 Hz) oscillatory component of the local field potential-plays a critical role in spatial navigation and memory by coordinating the activity of neuronal ensembles within the medial temporal lobe (MTL). Although theta has been extensively studied in freely moving rodents, its presence in humans has been elusive and primarily investigated in stationary subjects. Here we used a unique clinical opportunity to examine theta within the human MTL during untethered, real-world ambulatory movement. We recorded intracranial electroencephalographic activity from participants chronically implanted with the wireless NeuroPace responsive neurostimulator (RNS) and tracked their motion with sub-millimeter precision. Our data revealed that movement-related theta oscillations ind

SUBMITTER: M Aghajan Z 

PROVIDER: S-EPMC5937848 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature