Microstructural white matter alterations and hippocampal volumes are associated with cognitive deficits in craniopharyngioma.

ABSTRACT:

Context

Patients with craniopharyngioma (CP) and hypothalamic lesions (HL) have cognitive deficits. Which neural pathways are affected is unknown.

Objective

To determine whether there is a relationship between microstructural white matter (WM) alterations detected with diffusion tensor imaging (DTI) and cognition in adults with childhood-onset CP.

Design

A cross-sectional study with a median follow-up time of 22 (6-49) years after operation.

Setting

The South Medical Region of Sweden (2.5 million inhabitants).

Participants

Included were 41 patients (24 women, ≥17 years) surgically treated for childhood-onset CP between 1958-2010 and 32 controls with similar age and gender distributions. HL was found in 23 patients.

Main outcome measures

Subjects p

SUBMITTER: Fjalldal S 

PROVIDER: S-EPMC5937918 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature