Early life risk factors for chronic sinusitis: A longitudinal birth cohort study.

ABSTRACT:

Background

Chronic sinusitis is a commonly diagnosed condition in adults who frequently present with late-stage disease and irreversible changes to the sinus mucosa. Understanding the natural history of chronic sinusitis is critical in developing therapies designed to prevent or slow the progression of disease.

Objective

We sought to determine early life risk factors for adult sinusitis in a longitudinal cohort study (Tucson Children's Respiratory Study).

Methods

Physician-diagnosed sinusitis was reported at age 6. Adult sinusitis between 22 and 32 years was defined as self-reported sinusitis plus physician-ordered sinus radiologic films. Atopy was assessed by skin prick test. Individuals were grouped into 4 phenotypes: no sinusitis (n = 621), transient childhood sinu

SUBMITTER: Chang EH 

PROVIDER: S-EPMC5937937 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature