Translation is actively regulated during the differentiation of CD8⁺ effector T cells.

ABSTRACT: Translation is a critical process in protein synthesis, but translational regulation in antigen-specific T cells in vivo has not been well defined. Here we have characterized the translatome of virus-specific CD8⁺ effector T cells (T_eff cells) during acute infection of mice with lymphocytic choriomeningitis virus (LCMV). Antigen-specific T cells exerted dynamic translational control of gene expression that correlated with cell proliferation and stimulation via the T cell antigen receptor (TCR). The translation of mRNAs that encode translation machinery, including ribosomal proteins, was upregulated during the T cell clonal-expansion phase, followed by inhibition of the translation of those transcripts when the CD8⁺ T_eff cells stopped dividing jus

SUBMITTER: Araki K 

PROVIDER: S-EPMC5937989 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature