Brain and spinal cord injury repair by implantation of human neural progenitor cells seeded onto polymer scaffolds.

ABSTRACT: Hypoxic-ischemic (HI) brain injury and spinal cord injury (SCI) lead to extensive tissue loss and axonal degeneration. The combined application of the polymer scaffold and neural progenitor cells (NPCs) has been reported to enhance neural repair, protection and regeneration through multiple modes of action following neural injury. This study investigated the reparative ability and therapeutic potentials of biological bridges composed of human fetal brain-derived NPCs seeded upon poly(glycolic acid)-based scaffold implanted into the infarction cavity of a neonatal HI brain injury or the hemisection cavity in an adult SCI. Implantation of human NPC (hNPC)-scaffold complex reduced the lesion volume, induced survival, engraftment, and differentiation of grafted cells, increased neovascularizat

SUBMITTER: Shin JE 

PROVIDER: S-EPMC5938022 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature