Decipher reliable biomarkers of brain aging by integrating literature-based evidence with interactome data.

ABSTRACT: Aging is an inevitable progressive decline in every physiological function and serves as a primary risk factor for cognitive decline and Alzheimer's disease. Thus, age-dependent impairments in cognitive function must be understood in association with general aging processes with an integrative approach in a systemic manner. An integrative aging gene network was constructed based on mutual molecular interactions using literature-curated interactome data and separated into functionally distinct modules. To investigate key surrogate biomarkers of the aging brain in the context of the general aging process, co-expression networks were built on post-mortem and Alzheimer's brain transcriptome data. In both the normal aging brain and the brain affected by Alzheimer's disease, the immune-related c

SUBMITTER: Bae SH 

PROVIDER: S-EPMC5938059 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature