Mechanism for initiation of food allergy: Dependence on skin barrier mutations and environmental allergen costimulation.

ABSTRACT:

Background

Mechanisms for the development of food allergy in neonates are unknown but clearly linked in patient populations to a genetic predisposition to skin barrier defects. Whether skin barrier defects contribute functionally to development of food allergy is unknown.

Objective

The purpose of the study was to determine whether skin barrier mutations, which are primarily heterozygous in patient populations, contribute to the development of food allergy.

Methods

Mice heterozygous for the filaggrin (Flg)^ft and Tmem79^ma mutations were skin sensitized with environmental and food allergens. After sensitization, mice received oral challenge with food allergen, and then inflammation, inflammatory mediators, and anaphylaxis were measured.

Results</

SUBMITTER: Walker MT 

PROVIDER: S-EPMC5938139 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature