Synchronous immune alterations mirror clinical response during allergen immunotherapy.

ABSTRACT:

Background

Three years of treatment with either sublingual or subcutaneous allergen immunotherapy has been shown to be effective and to induce long-term tolerance. The Gauging Response in Allergic Rhinitis to Sublingual and Subcutaneous Immunotherapy (GRASS) trial demonstrated that 2 years of treatment through either route was effective in suppressing the response to nasal allergen challenge, although it was insufficient for inhibition 1 year after discontinuation.

Objective

We sought to examine in the GRASS trial the time course of immunologic changes during 2 years of sublingual and subcutaneous immunotherapy and for 1 year after treatment discontinuation.

Methods

We performed multimodal immunomonitoring to assess allergen-specific CD4 T-cell properties in parallel

SUBMITTER: Renand A 

PROVIDER: S-EPMC5938141 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature