BaTiO₃-core Au-shell nanoparticles for photothermal therapy and bimodal imaging.

ABSTRACT: We report sub-100 nm metal-shell (Au) dielectric-core (BaTiO₃) nanoparticles with bimodal imaging abilities and enhanced photothermal effects. The nanoparticles efficiently absorb light in the near infrared range of the spectrum and convert it to heat to ablate tumors. Their BaTiO₃ core, a highly ordered non-centrosymmetric material, can be imaged by second harmonic generation, and their Au shell generates two-photon luminescence. The intrinsic dual imaging capability allows investigating the distribution of the nanoparticles in relation to the tumor vasculature morphology during photothermal ablation. Our design enabled in vivo real-time tracking of the BT-Au-NPs and observation of their thermally-induced effect on tumor vessels.

Statement of significance

Phot

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5938150 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature