BIG1/Arfgef1 and Arf1 regulate the initiation of myelination by Schwann cells in mice.

ABSTRACT: During development of the peripheral nervous system in mammals, Schwann cells wrap their plasma membranes around neuronal axons, forming multiple myelin sheaths. A mature myelin sheath insulates axons and increases nerve conduction velocity while protecting nerve fibers from various stresses such as physical ones. Despite this functional importance, the molecular units that underlie dynamic morphological changes in formation of myelin sheaths are not sufficiently understood. Arf1 is a small guanosine triphosphate-binding protein that plays multiple roles in intracellular trafficking and related signaling, both of which are processes involved in cell morphogenesis. We demonstrate that the Arf1 guanine nucleotide exchange factor, brefeldin A-inhibited guanine nucleotide-exchange protein 1 (B

SUBMITTER: Miyamoto Y 

PROVIDER: S-EPMC5938228 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature