Beneficial Effects of Elderly Tailored Mediterranean Diet on the Proteasomal Proteolysis.

ABSTRACT: Aging is a multifactorial process characterized by the accumulation of proteins undergoing oxidative modifications, either due to enhanced levels of oxidative stress or due to their decreased clearance; both facts are related to the establishment of chronic inflammatory processes. These processes are directly associated with functional and structural modifications of a key cellular component, namely the proteasome. In this study, levels of oxidized proteins, along with proteasome and immunoproteasome composition and activity on a selected group of 120 elderly volunteers were analyzed before and after the administration of a specific dietary protocol, based on an elderly tailored Mediterranean diet (the "NU-AGE diet"). A significant negative correlation between levels of oxidized/carbonylat

SUBMITTER: Athanasopoulou S 

PROVIDER: S-EPMC5938393 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature