Genetic Insights Into Frailty: Association of 9p21-23 Locus With Frailty.

ABSTRACT: Frailty is a complex aging phenotype associated with increased vulnerability to disability and death. Understanding the biological antecedents of frailty may provide clues to healthy aging. The genome-wide association study hotspot, 9p21-23 region, is a risk locus for a number of age-related complex disorders associated with frailty. Hence, we conducted an association study to examine whether variations in 9p21-23 locus plays a role in the pathogenesis of frailty in 637 community-dwelling Ashkenazi Jewish adults aged 65 and older enrolled in the LonGenity study. The strongest association with frailty (adjusted for age and gender) was found with the SNP rs518054 (odds ratio: 1.635, 95% CI = 1.241-2.154; p-value: 4.81 × 10^-04) intergenic and located between LOC105375977 and

SUBMITTER: Sathyan S 

PROVIDER: S-EPMC5938407 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature